The 4 p.m. game is the first football meeting between the two schools.
It also marks the first time quarterbacks Lendon Redwine and Colton Bailey will face each other.
Redwine, a freshman who played his prep football at Dobyns-Bennett, will get his second start for UVa-Wise (1-4, 0-3). His first outing as a starter was a tough one last weekend against No. 8 Lenoir-Rhyne.
Despite a tough outing in a 63-6 loss to the Bears, Redwine did throw his first career touchdown, a 4-yard pass to Seth Phillips at the 7:21 mark of the third quarter.
The TD pass accounted for the only points of the game for the Cavaliers.
Redwine finished the game completing 15 of 29 passes for 71 yards with a touchdown and two interceptions.
Redwine saw late-game action two weeks ago against Carson-Newman. In the final quarter of that game, he completed 3 of 6 passes for 31 yards with one interception.
The Cavs will be looking to generate more offense this weekend against Newberry, but throwing the ball could be a tough assignment.
The Wolves (1-4, 0-3) have five different defenders who have recorded an interception this season.
Like Redwine, Bailey, a freshman, will get his second straight start for the Wolves on Saturday.
In a 20-19 loss to Mars Hill last week, Bailey completed 10 of 25 passes for 163 yards and two touchdowns, while rushing for 49 yards.
Two weeks ago, Bailey threw three touchdowns after coming off the bench to help Newberry to its only win in a 30-20 victory over Tusculum.
UVa-Wise will counter defensively with redshirt junior Marcus Tarrer. He leads the team, and is second in the SAC, in tackles with 43.
WASPS LOOK TO KEEP WINNING WAYS
Emory & Henry looks to pick up its second straight Old Dominion Athletic Conference win Saturday with a trip to Southern Virginia (2-2, 1-2).
The Wasps (2-2, 1-1) rolled past Hampden-Sydney last weekend with a 56-17 win.
Abingdon grad Derrick Yates played a big role in the Emory & Henry win. He caught 13 passes for 265 yards, an E&H record for most receiving yards in a single game. Yates also hauled in three touchdown passes in the win.
In addition to setting the school mark for most yards in a game, Yates also set E&H career marks for 174 receptions, 30 receiving touchdowns and 2,652 receiving yards.
The offensive attack will also include quarterback Hunter Taylor, who completed 26 of 35 passes for 391 yards with five touchdowns and two interceptions. He also rushed for 26 yards and another touchdown.
The Wasps defensive attack includes sophomore linebacker Ivan Phillips. The Dobyns-Bennett graduate had nine tackles, including two for loss, in last week’s win.
E&H senior Jayden Rosenboro, a Tennessee High grad, along with junior Daniel Flowe and sophomore Jaylyn Kreimes each had interceptions last week for the Wasps.
Kickoff for the E&H at Southern Virginia game is set for 1 p.m. Saturday.